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Updated: Jun 27, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Acquired haemoglobin H disease associated with myelodysplastic syndrome
Syed Qamar Abbas1, Nasiruddin, Mohammed Misfer Al-Gethami
1Department of Internal Medicine, Armed Forces Hospital, Sharourah, Kingdom of Saudi Arabia. qamarchk@yahoo.com
Abstract:
A 60-year-old male patient presented with jaundice. Initial investigations showed anemia, indirect hyperbilirubinemia, raised Lactic Dehydrogenase (LDH) and increased reticulocyte count suggestive of hemolysis. Considering hemolysis low MCV and basophilic stippling on peripheral film, hemoglobin electrophoresis was done that showed Haemoglobin H (15.5%) that in the absence of family history was thought to be acquired. After bone marrow examination, the final diagnosis was Myelodysplastic Syndrome (MDS), Refractory anemia with excess of blast (RAEB) associated with acquired Haemoglobin H (Hb H) disease.
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