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A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
Published on: November 6, 2020
[Risk factors for death due to fungal septicemia and prognostic analysis]
Zhong Yu1, Jun Jiang, Ri-Fang Liao
1Department of Gastroenterology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. yuzhong.gd@163.com
Objective:
To analyze the incidence, clinical features and the predisposing factors of fungal septicemia, and investigate the risk factors for death due to fungal septicemia and the prognosis of the patients.
Methods:
We retrospectively analyzed the clinical data of 91 patients with fungal septicemia diagnosed in the last 17 years, including 60 patients with clinical cure or improvement, and 31 who die of the disease. Based on the results by univariate analysis, the data were analyzed using logistic multiple regression and Fisher's discriminant analysis.
Results:
Fungal septicemia had many predisposing factors with high mortality rate. Univariate analysis revealed significant differences between the cured/improved cases and the fatal cases for 12 variables, including advanced age, complication by bacterial infection, septic shock, multiple organ dysfunction syndrome (MODS), ICU patients, cortical hormone therapy, surgery, chemotherapy, use of immunopotentiating agents, length of hospital stay before antifungal therapy, time of anti-fungus therapy and types of invasive procedures. Logistic multiple regression analysis showed that the types of invasive procedures, MODS, surgery and prolonged hospital stay before antifungal therapy were the independent risk factors for fungal septicemia-related death. Fisher's linear discriminant equation was established for predicting the prognosis of the disease.
Conclusion:
The types of invasive procedure, MODS, surgery and prolonged hospital stay before antifungal therapy are the independent risk factors for fungal septicemia-related death, and the patients' prognosis can be predicted using Fisher's linear discriminant equation.
Insights
Fungal septicemia has high mortality. Invasive procedures, multiple organ dysfunction syndrome (MODS), surgery, and prolonged hospital stays are key risk factors for death, aiding prognosis prediction.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Medical Mycology
Context:
- Fungal septicemia poses a significant threat with high mortality rates.
- Understanding predisposing factors and risk factors for death is crucial for patient outcomes.
Purpose:
- To analyze the incidence, clinical features, and predisposing factors of fungal septicemia.
- To investigate risk factors for mortality and patient prognosis in fungal septicemia.
Summary:
- Retrospective analysis of 91 fungal septicemia patients over 17 years identified key differences between survivors and non-survivors.
- Independent risk factors for death included invasive procedures, multiple organ dysfunction syndrome (MODS), surgery, and prolonged hospital stay before antifungal therapy.
Impact:
- Identifies critical risk factors for fungal septicemia-related mortality.
- Establishes a predictive model (Fisher's linear discriminant equation) for patient prognosis.
- Informs clinical management strategies to improve outcomes for patients with fungal septicemia.
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