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Updated: May 27, 2026

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease
Published on: March 29, 2024
[Clinical analysis of leptomeningeal carcinomatosis in 4 cases]
Jian Bao1, Xue-Qiang Hu, Ying Jiang
1Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Objective:
To analyze the characteristics of leptomeningeal carcinomatosis.
Methods:
We summarized the clinical presentation, magnetic resonance imaging (MRI) findings and cerebrospinal fluid (CSF) cytological findings in 4 cases of leptomeningeal carcinomatosis.
Results:
All the patients presented with signs of elevated intracranial pressure such as headache. Enlarged cerebral ventricles and dural enhancement were found by MRI, with also the presence of malignant cells in cytological slides.
Conclusion:
CSF cytological examination is important for diagnosis of leptomeningeal carcinomatosis.
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