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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

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Published on: March 17, 2023

Stem cell bioprocessing: fundamentals and principles.

Mark R Placzek¹, I-Ming Chung, Hugo M Macedo

¹Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Journal of the Royal Society, Interface

|November 27, 2008

Summary

This summary is machine-generated.

Stem cell bioprocessing is key for regenerative medicine. Engineering principles ensure safe, reproducible stem cell therapies, moving lab success to clinical applications for better patient outcomes.

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Area of Science:

Regenerative Medicine
Tissue Engineering
Biotechnology

Background:

Stem cell research shows significant potential for tissue engineering and regenerative medicine.
The first adult stem cell organ transplant in 2006 demonstrated clinical benefits for myelomeningocele patients.

Purpose of the Study:

To review the principles required for successful stem cell bioprocessing.
To address the translation of laboratory stem cell culture to clinical therapeutics.

Main Methods:

Application of engineering principles to stem cell bioprocessing.
Integration of fundamental research (developmental biology, 'omics', immunology) and industrial practices (biologics).

Main Results:

Successful stem cell bioprocessing requires control, reproducibility, automation, validation, and safety.
Cross-disciplinary collaboration is essential for advancing TERM.

Conclusions:

Bioprocess technologies are crucial for translating stem cell therapies to the clinic.
Avoiding past commercialization failures in marketing, pricing, and production is critical for success.