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Updated: Jun 27, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

Clinical characteristics and prognosis of orbital invasive aspergillosis

Hye Sun Choi1, Jun Yong Choi, Jin Sook Yoon

  • 1Department of Ophthalmology, Kim's Eye Hospital, Yonsei University College of Medicine, Seoul, Korea.

Ophthalmic Plastic and Reconstructive Surgery
|November 27, 2008
PubMed
Abstract

Insights

Orbital invasive aspergillosis, a serious fungal infection, has a high mortality rate, especially when diagnosis is delayed. Fever and misdiagnosis are key indicators of poor prognosis in these immunocompromised patients.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Orbital invasive aspergillosis is a severe condition impacting immunocompromised individuals.
  • It is a significant contributor to patient morbidity and mortality.

Purpose of the Study:

  • To assess the clinical features and patient outcomes of orbital invasive aspergillosis.
  • To identify risk factors associated with mortality in affected patients.

Main Methods:

  • A retrospective cohort study analyzed 15 cases of orbital invasive aspergillosis.
  • Data collected included clinical characteristics, radiologic findings, and underlying conditions.
  • Statistical analysis identified risk factors for mortality.

Main Results:

  • The study included 15 patients with a mean age of 61.9 years.
  • Common factors included diabetes mellitus and concurrent paranasal sinus infections.
  • Ocular symptoms like visual disturbance, periorbital swelling, and pain were prevalent.
  • The mortality rate was 40%, with fever and incorrect initial diagnosis linked to increased mortality.

Conclusions:

  • Fever and delayed or incorrect initial diagnosis are associated with higher mortality.
  • Early diagnosis and effective treatment strategies require further investigation.

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