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Updated: Jun 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Low-grade sebaceous carcinoma presenting on the leg
Sumihisa Imakado1, Kazutoshi Hamada, Keiko Miura
1Department of Dermatology, Japanese Red Cross Medical Center, Division of Surgical Pathology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. sumihisa-imakado@triton.ocn.ne.jp
A rare case of low-grade sebaceous carcinoma, a type of skin cancer, was found on the leg of an elderly woman. This finding highlights the unusual presentation of this rare cancer in this anatomical location.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Sebaceous carcinoma is a rare malignant neoplasm originating from sebaceous glands.
- While commonly occurring on the face and eyelids, its occurrence on the lower extremities is exceptionally uncommon.
Observation:
- An 80-year-old female patient presented with a keratotic plaque on the left popliteal fossa.
- The lesion measured 1.4x1.3 cm.
Findings:
- Surgical resection of the plaque was performed.
- Microscopic examination confirmed the diagnosis of low-grade sebaceous carcinoma.
Implications:
- This case underscores the possibility of sebaceous carcinoma presenting in atypical locations like the leg.
- Further investigation into the risk factors and diagnostic challenges of extracephalic sebaceous carcinoma may be warranted.
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