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Published on: March 21, 2018

A pair of twins born after maternal exposure to leflunomide

K Heine1, C F Poets

  • 1Department of Neonatology, University Children's Hospital, Tübingen, Germany.

Journal of Perinatology : Official Journal of the California Perinatal Association
|November 27, 2008
PubMed

Leflunomide is a drug used in rheumatoid arthritis with teratogenic and fetotoxic effects. Clinical data on human pregnancies are limited to a few case reports without detailed information whether the mothers did have a washout procedure as suggested by the manufacturer or what type of malformation the offspring showed. We report on a set of twins born after maternal exposure to leflunomide who had a largely normal neonatal outcome, providing information about the washout procedure and the blood level of the active metabolite.

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