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Updated: Jun 27, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
Published on: November 26, 2018
First responders: understanding monocyte-lineage traffic in the acutely injured kidney
Sundararaman Swaminathan1, Matthew D Griffin
1Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. sswaminathan@uams.edu
Abstract:
Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two chemokine receptors that regulate monocyte traffic. This Commentary examines the degree to which monocyte-lineage diversity, trafficking, and contribution to renal injury have been teased out to date.
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