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Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: a multicenter phase
Kyung Hee Lee1, Min Kyoung Kim, Yeol Hong Kim
1Division of Hemato-Oncology, College of Medicine, Yeungnam University, Daegu, South Korea.
Purpose:
Gemcitabine is the only drug approved for single-agent therapy in advanced pancreatic carcinoma (APC). Gemcitabine-based combination chemotherapy has not yet shown promising results.
Methods:
This multicenter phase II study enrolled previously untreated patients with locally advanced and/or metastatic pancreatic adenocarcinoma. Patients received 1,000 mg/m(2) gemcitabine, 100-min infusion, day 1 and 100 mg/m(2) oxaliplatin, 2-h infusion, day 2; q2w. The primary end point was response rate (RR).
Results:
Thirteen study centers enrolled 48 eligible patients of which 44 were evaluable. The RR, median overall survival, and median time to progression were 18.2%, 9.4 and 5.6 months, respectively. Sixteen patients (36.4%) experienced clinical benefit. The global quality of life scores improved by 11.71. Grade 3/4 peripheral sensory neuropathy was noted (2.1%), while the most common hematologic toxicity was anemia (grade 3/4, 6.3%).
Conclusions:
Gemcitabine and oxaliplatin combination chemotherapy showed a promising activity in APC patients and was well tolerated.
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