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Published on: April 5, 2011
Cefepime-induced nonconvulsive status epilepticus: case report and review
Farah Thabet1, Mohamed Al Maghrabi, Ahmed Al Barraq
1Department of Pediatrics, Al-Hada Armed Forces Hospital, P.O. Box 1347, Taif, Saudi Arabia.
Introduction:
A case of cefepime-induced nonconvulsive status epilepticus in a 15-year-old child with end stage renal disease on hemodialysis is reported. Clinical symptoms and EEG dramatically improved 48 h after discontinuation of cefepime.
Methods:
Twenty-five cases of nonconvulsive status epilepticus associated with cefepime that have been reported in the literature are reviewed.
Results:
The average age was 60 years [15-86], our patient is the second pediatric patient reported, and 56% of cases occurred in women. The cefepime dosage was adjusted to the renal function in 5 cases. All except 1 patient have impaired renal function (CRF: 17 cases, ARF: 7 cases). The symptoms start 1-15 days after starting cefepime, mean 6 days. The outcome was good after discontinuation of cefepime therapy and anticonvulsant treatment, but lethal outcome was also reported in 2 cases. One fatality was related to status epilepticus.
Conclusion:
The clinicians' awareness must be increased about cefepime-induced nonconvulsive status epilepticus.
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