Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Diabetes Mellitus: Introduction

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

Type I Diabetes III: Clinical Manifestations

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retrospective multicenter analysis of causes of death in wild mammals in Southern Germany (2019-2023).

Frontiers in veterinary science·2026

Same author

Photosensitisation and green egg yolks in laying hens caused by the feeding of ensiled alfalfa leaves.

British poultry science·2022

Same author

Search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector boson pairs in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021

Same author

Search for a heavy vector resonance decaying to a <math></math> boson and a Higgs boson in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021

Same author

Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at <math> </math>.

The European physical journal. C, Particles and fields·2021

Same author

Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals

In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals

Published on: February 26, 2022

[Diabetes mellitus type 1 in a goat].

U Braun¹, B Gansohr, M Seidel

¹Klinik für Wiederkäuer der Universität Zürich, Zürich. ubraun@vetclinics.uzh.ch

Schweizer Archiv Fur Tierheilkunde

|November 27, 2008

Summary

This case report details a four-year-old goat diagnosed with type I diabetes mellitus. The animal was successfully managed with insulin for nearly four years, highlighting long-term diabetes care possibilities in goats.

More Related Videos

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Related Experiment Videos

Last Updated: Jun 27, 2026

In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals

In Vivo Methods to Assess Retinal Ganglion Cell and Optic Nerve Function and Structure in Large Animals

Published on: February 26, 2022

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Area of Science:

Veterinary Medicine
Endocrinology
Animal Health

Background:

Type I diabetes mellitus is a chronic condition affecting glucose regulation.
Documenting diabetes mellitus in goats provides valuable comparative data for animal endocrinology.
This report focuses on a specific case to illustrate clinical presentation and management.

Observation:

A four-year-old goat presented with classic diabetes mellitus signs: weight loss, polydipsia, and polyuria.
Urinalysis confirmed glucosuria, ketonuria, and aciduria.
Hematological findings included anemia likely due to parasitism, alongside hyperglycemia and hypoinsulinemia.

Findings:

The goat received twice-daily subcutaneous insulin injections for nearly four years.
Treatment effectively managed the diabetic condition.
At eight years old, the goat developed bronchopneumonia and was euthanized.

Implications:

Pancreatic beta-cell degeneration was confirmed postmortem, consistent with type I diabetes.
This case demonstrates the feasibility of long-term insulin management in diabetic goats.
Findings contribute to understanding diabetes mellitus in non-domesticated species and potential veterinary treatment strategies.