Related Experiment Video
Updated: Jun 27, 2026

Isolation, Characterization, and Proteomic Analysis of Plasma-Derived Extracellular Vesicles for Cardiovascular Biomarker Discovery
Published on: January 31, 2025
Variability, heritability and environmental determinants of human plasma N-glycome
Ana Knezević1, Ozren Polasek, Olga Gornik
1Department of Biochemistry and Molecular Biology, University of Zagreb, Zagreb, Croatia.
Abstract:
Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.
Related Concept Videos
Heritability
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Principles of Pharmacogenetics: Types of Genetic Variants
Polygenic Traits
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Gene-Environment Interactions
