Related Experiment Video
Updated: Jun 27, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
Protecting against intergenerational problem behavior: mediational effects of prevented marijuana use on
Nathaniel R Riggs1, Chih-Ping Chou, Mary Ann Pentz
1University of Southern California, Institute for Prevention Research, 1000 S. Fremont Avenue, Unit #8, Alhambra, CA 91803, United States. nriggs@usc.edu
Background:
The aims of the study were to identify pathways from parent marijuana use to child problem behavior and parent-child relationships, and to evaluate whether effects of an earlier prevention program delivered to parents when they themselves were early adolescents would have a protective effect on these relationships one generation later.
Methods:
Structural equation models were applied to the data of a second-generation study of a drug abuse prevention trial. Models assessed whether there were sustained marijuana prevention effects on adults who had at least one school-age child at the end of the emerging adulthood period (age 26, n=257), and whether these effects mediated subsequent parent-child relationships and child impulsivity when parents were between the ages of 28 and 34.
Results:
Participants originally assigned to the program group used significantly less marijuana in early adulthood than did controls. In turn, parental marijuana use was positively related to child impulsivity and negatively to parental warmth, but not significantly related to parental aggression.
Conclusions:
Results suggest both a direct relationship from parental marijuana use to child impulsivity, as well as indirect relationships through parent-child interactions. Results also strongly support a role for early adolescent prevention programs for drug use, both for participants' own long-term benefit, as well as for the benefit of their future children.
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