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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.

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Related Experiment Video

Updated: Jun 27, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe
06:04

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Epilepsy surgery in patients with multiple cerebral cavernous malformations.

R Rocamora1, I Mader, J Zentner

  • 1Epilepsy Center, University of Freiburg, Breisacher Str. 64, D-79106 Freiburg, Germany. rrocamora@ruberinternacional.es

Seizure
|November 28, 2008
PubMed
Summary

Epilepsy surgery for multiple cerebral cavernous malformations (CCMs) can be effective if the epileptogenic CCM is precisely identified. Outcomes are comparable to single CCM cases, though de novo CCMs or dual pathology may impact results.

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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

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Area of Science:

  • Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Cerebral cavernous malformations (CCMs) are vascular malformations often linked to intractable epilepsy.
  • Surgical indications for single CCMs are established, but data on multiple CCMs are limited.

Purpose of the Study:

  • To evaluate diagnostic criteria and postoperative outcomes for epilepsy surgery in patients with multiple CCMs and refractory epilepsy.
  • To clarify the efficacy of surgical intervention for medically intractable epilepsy associated with multiple CCMs.

Main Methods:

  • Retrospective analysis of clinical records from hospitalized patients.
  • Comprehensive diagnostic work-up including long-term video-EEG monitoring was performed.

Main Results:

  • Eleven out of 63 patients (17%) with CCMs and refractory epilepsy had multiple CCMs and underwent surgery.
  • Eight-one percent (9/11) achieved seizure freedom (Engel Ia) at 2-year follow-up.
  • Higher epileptogenicity was observed in temporal lobe CCMs; one case showed dual pathology, another de novo CCM appearance.

Conclusions:

  • Epilepsy surgery in multiple CCM patients yields favorable outcomes comparable to single CCM cases when the epileptogenic focus is accurately identified.
  • The potential for de novo CCMs or dual pathology necessitates careful consideration as these factors can negatively influence long-term results.