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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Updated: Jun 27, 2026

Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
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Cranial reconstruction after a post-craniotomy empyema.

J-F Chabas1, C Dellavolpe, Y Riah

  • 1Department of plastic and reconstructive surgery, Hôpital Nord, chemin des Bourrelly 13915 Marseille Cedex 20, France. jeff.chabas@neuf.fr

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|November 28, 2008
PubMed
Summary

This study reports a successful cranioplasty using a bioceramic implant and free flap for skull reconstruction after infection. The procedure restored neurological function and social life, demonstrating effective treatment for large skull defects.

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Area of Science:

  • Neurosurgery
  • Plastic and Reconstructive Surgery

Background:

  • Post-craniotomy empyema with osteitis can lead to extensive skull defects requiring complex reconstruction.
  • Reconstruction of large cranial defects, especially in infected fields, presents significant surgical challenges.

Observation:

  • A case report details cranioplasty for a large (120 cm²) skull defect following post-craniotomy empyema and osteitis.
  • The reconstruction utilized a bioceramic implant combined with a latissimus dorsi and serratus anterior muscular free flap.

Findings:

  • The combined approach successfully covered the wide skull defect and filled intracranial dead space.
  • Post-operatively, the patient showed significant neurological improvement, including correction of hemiparesis andphasic disorders.
  • Eight-month follow-up revealed no infection recurrence, no skull distortion, and a return to normal social life, with CT scans showing cerebral hemisphere re-expansion.

Implications:

  • This single-stage procedure effectively reconstructs extensive skull defects in previously infected areas.
  • The use of customized biomaterials and muscular free flaps offers a viable solution for complex cranial reconstruction.
  • The technique shows potential for restoring both functional and aesthetic outcomes in patients with severe cranial defects.