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Related Experiment Videos

Translocation (14;19) in acute biphenotypic leukemia.

R Carter1, I Dubé, T McKeithan

  • 1University of Toronto Hospitals Cancer Cytogenetics Program, Ontario, Canada.

Cancer Genetics and Cytogenetics
|May 1, 1991
PubMed
Summary

The rare translocation (14;19) typically seen in chronic lymphocytic leukemia was found in a patient with acute leukemia. This case highlights biophenotypic leukemia with both myeloid and B-cell characteristics.

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Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • The chromosomal rearrangement t(14;19)(q32;q13.1) is linked to B-cell chronic lymphocytic leukemia and lymphoma.
  • Molecular studies implicate the immunoglobulin heavy chain gene and the BCL3 oncogene in this translocation.

Observation:

  • This report details the first documented instance of t(14;19) in a patient diagnosed with acute leukemia.
  • The patient's leukemic cells exhibited characteristics of both myeloid and B-lymphoid lineages.

Findings:

  • Cytogenetic, molecular genetic, cell surface marker, cytochemistry, and electron microscopy analyses confirmed the biophenotypic nature of the leukemic cells.
  • The findings indicate a complex cellular origin for acute leukemia associated with the t(14;19) translocation.

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Implications:

  • This case expands the known spectrum of leukemias associated with t(14;19).
  • Understanding the biophenotypic nature is crucial for accurate diagnosis and targeted therapy in acute leukemia.
  • Further research is needed to elucidate the role of t(14;19) in acute biophenotypic leukemia.