Related Experiment Videos
Translocation (14;19) in acute biphenotypic leukemia
R Carter1, I Dubé, T McKeithan
1University of Toronto Hospitals Cancer Cytogenetics Program, Ontario, Canada.
Cancer Genetics and Cytogenetics
|May 1, 1991
Summary
The rare translocation (14;19) typically seen in chronic lymphocytic leukemia was found in a patient with acute leukemia. This case highlights biophenotypic leukemia with both myeloid and B-cell characteristics.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- The chromosomal rearrangement t(14;19)(q32;q13.1) is linked to B-cell chronic lymphocytic leukemia and lymphoma.
- Molecular studies implicate the immunoglobulin heavy chain gene and the BCL3 oncogene in this translocation.
Observation:
- This report details the first documented instance of t(14;19) in a patient diagnosed with acute leukemia.
- The patient's leukemic cells exhibited characteristics of both myeloid and B-lymphoid lineages.
Findings:
- Cytogenetic, molecular genetic, cell surface marker, cytochemistry, and electron microscopy analyses confirmed the biophenotypic nature of the leukemic cells.
- The findings indicate a complex cellular origin for acute leukemia associated with the t(14;19) translocation.
Implications:
- This case expands the known spectrum of leukemias associated with t(14;19).
- Understanding the biophenotypic nature is crucial for accurate diagnosis and targeted therapy in acute leukemia.
- Further research is needed to elucidate the role of t(14;19) in acute biophenotypic leukemia.