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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy.

Eosu Kim1, Jeonghun Ku, Kee Namkoong

  • 1Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.

Brain : a Journal of Neurology
|November 28, 2008
PubMed
Summary
This summary is machine-generated.

Resting-state functional connectivity analysis reveals that memory function in Wernicke

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Published on: July 31, 2019

Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Wernicke's encephalopathy (WE) pathogenesis and recovery mechanisms remain unclear.
  • Assessing memory function and its neural basis in WE patients is challenging.

Purpose of the Study:

  • To evaluate resting-state functional connectivity (rsFC) for assessing memory function in WE recovery.
  • To investigate the neural correlation between rsFC and the mammillothalamic tract in WE patients.

Main Methods:

  • Functional connectivity MRI scans were performed on 7 recovering WE patients, 14 alcoholic controls, and 14 healthy controls.
  • rsFC between anterior thalamus and mammillary bodies was measured via signal temporal correlations.
  • Verbal and non-verbal memory tests were administered after at least one month of alcohol abstinence.

Main Results:

  • Significant differences in left anterior thalamus-mammillary body rsFC were found between WE patients and healthy controls (P = 0.014).
  • Alcoholic controls showed intermediate rsFC, significantly different from healthy controls (P = 0.038).
  • Left-sided rsFC strongly correlated with delayed verbal recall (r = 0.771, P = 0.042) and recognition (r = 0.825, P = 0.022) in WE patients.

Conclusions:

  • Memory function in WE recovery is linked to mammillothalamic tract functional connectivity.
  • rsFC analysis is a practical, non-invasive method for evaluating the mammillothalamic tract in living WE patients.