Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-inflammatory roles of ultraviolet radiation in cutaneous photocarcinogenesis.

Photochemistry and photobiology·2026
Same author

Disrupted epigenetic regulation in human senile lentigines revealed by characterizing gene expression and DNA methylation alterations.

Clinical epigenetics·2026
Same author

Clinical Practice Guidelines for the Management of Porphyrias in Japan: Secondary Publication (English Translation).

The Journal of dermatology·2026
Same author

Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.

Cell genomics·2025
Same author

Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder.

Cell genomics·2025
Same author

Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice.

Journal of dermatological science·2025

Related Experiment Video

Updated: Jun 27, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

Molecular clocks in mouse skin.

Miki Tanioka1, Hiroyuki Yamada, Masao Doi

  • 1Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan.

The Journal of Investigative Dermatology
|November 28, 2008
PubMed
Summary

Skin clock genes show daily rhythms driven by an intrinsic molecular clock, not just light. This internal clock in skin cells is crucial and relies on signals from the brain's central clock.

More Related Videos

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

Area of Science:

  • Chronobiology
  • Dermatology
  • Molecular Biology

Background:

  • Skin cells exhibit daily rhythms in gene expression.
  • The drivers of these circadian rhythms (external light vs. internal mechanisms) remain unclear.

Purpose of the Study:

  • To investigate the intrinsic mechanisms driving circadian rhythms in mouse skin.
  • To determine the role of the suprachiasmatic nucleus (SCN) and external light in maintaining skin circadian rhythms.

Main Methods:

  • Analysis of clock gene expression in mouse skin under constant darkness.
  • Assessment of skin circadian rhythms in Cry1/Cry2 knockout mice lacking a molecular clock.
  • Examination of PER2 protein localization and timing in epidermal keratinocytes.
  • Investigation of skin clock gene expression following SCN ablation.

Main Results:

  • Robust circadian rhythms in clock gene expression were observed in mouse skin under constant dark conditions.
  • These rhythms were abolished in mice lacking the core molecular clock components (Cry1/Cry2 knockout).
  • PER2 protein rhythmically localized to the nuclei of epidermal and hair follicle keratinocytes.
  • Skin circadian rhythms ceased upon SCN ablation and were not restored by standard light-dark cycles.

Conclusions:

  • The epidermis possesses an intrinsic, self-sustaining molecular clock.
  • Signaling from the central SCN clock is essential for maintaining skin circadian rhythms.
  • External light cues cannot compensate for the loss of SCN signaling in regulating the skin clock.