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Updated: Jun 27, 2026
08:19
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
Published on: July 7, 2020
Polymyxins: a review of the current status including recent developments
Andrea L Kwa1, Vincent H Tam, Matthew E Falagas
1Department of Pharmacy, Singapore General Hospital, Singapore. andrea.kwa.l.h@sgh.com.sg
Annals of the Academy of Medicine, Singapore
|November 28, 2008
Summary
Polymyxins are crucial for treating multidrug-resistant gram-negative infections in Singapore due to limited alternatives. Urgent research is needed to address information gaps and preserve this vital antibiotic class.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- Polymyxins are essential for treating multidrug-resistant gram-negative bacilli in Singapore.
- These bacteria exhibit susceptibility only to aminoglycosides and polymyxins, or polymyxins alone.
- There is a lack of novel antibiotics targeting these challenging infections.
Purpose of the Study:
- To review existing literature on polymyxins.
- To summarize clinical studies and relevant information for informed polymyxin prescription.
- To highlight critical information gaps requiring urgent attention.
Main Methods:
- Comprehensive literature search of all published studies on polymyxins.
- Inclusion of all relevant literature up to February 2008.
- Review focused on clinical studies and prescribing information.
Main Results:
- The review provides a summary of current polymyxin literature.
- Highlights clinical studies and information to guide polymyxin use.
- Identifies areas needing further investigation.
Conclusions:
- Substantial information gaps exist regarding polymyxin use.
- Urgent research is necessary to fill these gaps.
- Addressing these gaps is crucial for preserving polymyxins as a last-line antibiotic.
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