Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote Tonometry Identifies Significant Variability in the Timing of Intraocular Pressure Response to Topical Medication Change.

Ophthalmology. Glaucoma·2026
Same author

The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo.

Science translational medicine·2026
Same author

Deep learning method for semi-automated segmentation of optic nerve head tissues in optical coherence tomography images.

Experimental eye research·2025
Same author

Crowd-Sourced Glaucoma Study. Definition of Glaucoma for Research by a Large Group of Global Expert Evaluators.

American journal of ophthalmology·2025
Same author

Cellular responses to short-term intraocular pressure elevation in a porcine eye explant model.

Experimental eye research·2025
Same author

Prevalence of Glaucoma in Europe and Projections to 2050: Findings from the European Eye Epidemiology Consortium.

Ophthalmology·2025
Same journal

Trends in pediatric uveitis: A systematic review and meta-epidemiological investigation of geographic, economic, and climate factors.

Survey of ophthalmology·2026
Same journal

Efficacy and safety of different intraocular therapies for non-infectious uveitis: A network meta-analysis.

Survey of ophthalmology·2026
Same journal

Macular telangiectasia masqueraders.

Survey of ophthalmology·2026
Same journal

Utilization of anterior segment optical coherence tomography in childhood glaucoma: A systematic review.

Survey of ophthalmology·2026
Same journal

Peripapillary pachychoroid syndrome: Clinical and imaging features, diagnostic differentiation and therapeutic strategies.

Survey of ophthalmology·2026
Same journal

Prognostic factors and postoperative outcomes in pediatric cataract patients: A systematic review and meta-analysis.

Survey of ophthalmology·2026
See all related articles

Related Experiment Videos

Adherence and persistence with glaucoma therapy.

Gail F Schwartz1, Harry A Quigley

  • 1Greater Baltimore Medical Center, Baltimore, Maryland 21204, USA.

Survey of Ophthalmology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Patient adherence and persistence with glaucoma medications are critical but often poor, impacting treatment effectiveness. Understanding patient behaviors and improving physician awareness are key to better glaucoma management.

Related Experiment Videos

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Patient Adherence Research

Background:

  • Chronic therapies, particularly for glaucoma, require high adherence and persistence to prevent disease progression.
  • Patient-reported adherence often contradicts pharmacy claims data, highlighting a significant gap in understanding real-world medication use.

Purpose of the Study:

  • To review literature on methods for assessing adherence and persistence in chronic therapies.
  • To identify patient behaviors that challenge effective glaucoma treatment.
  • To emphasize the need for increased physician awareness of adherence issues.

Main Methods:

  • Literature review of studies assessing adherence and persistence in chronic therapies.
  • Analysis of patient behaviors impacting medication adherence.
  • Examination of findings from The Glaucoma Adherence and Persistency Study.

Main Results:

  • Persistence rates for glaucoma medications are frequently below 50% at one year.
  • Differentiating eyedrop efficacy from non-adherence is a challenge in ophthalmic treatment.
  • "White-coat adherence" and medication cycling are common behaviors that complicate long-term IOP control assessment.

Conclusions:

  • Adherence and persistence rates vary by drug class, with prostaglandins showing higher rates.
  • Physician awareness of adherence challenges is crucial for improving patient compliance.
  • Addressing adherence issues is essential for effective long-term glaucoma management.