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Related Experiment Video

Updated: Jun 27, 2026

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

Destination therapy: current results and future promise.

Katherine Lietz¹, Leslie W Miller

¹Center for Advanced Cardiac Care, Columbia-Presbyterian Medical Center, New York, New York 10032, USA. KL2384@columbia.edu

Seminars in Thoracic and Cardiovascular Surgery

|November 29, 2008

Summary

Left ventricular assist devices (LVADs) offer superior treatment over medical therapy for end-stage heart failure patients ineligible for transplantation. Destination therapy (DT) with LVADs is a proven alternative to heart transplantation.

Related Experiment Videos

Last Updated: Jun 27, 2026

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

Area of Science:

Cardiology
Medical Devices
Heart Failure Management

Background:

End-stage heart failure patients often lack transplantation options.
Medical therapy alone has limited efficacy in advanced heart failure.
Left ventricular assist devices (LVADs) emerged as a potential alternative.

Purpose of the Study:

To review clinical trials and outcomes of destination therapy (DT) using LVADs.
To assess LVADs as an alternative to heart transplantation for ineligible patients.
To summarize current knowledge and future directions in mechanical circulatory support.

Main Methods:

Review of landmark trials: REMATCH, INTREPID, and CUBS.
Analysis of post-REMATCH era destination therapy outcomes in the US.
Synthesis of existing data on permanent mechanical circulatory support.

Main Results:

The REMATCH trial established LVADs as superior to medical therapy for eligible patients.
DT with LVADs provides a viable alternative for patients not candidates for heart transplant.
Early outcomes in the post-REMATCH era demonstrate continued efficacy.

Conclusions:

Destination therapy with LVADs is a superior treatment option for select end-stage heart failure patients.
Mechanical circulatory support represents a significant advancement in heart failure management.
Ongoing research and development are crucial for future directions in LVAD therapy.