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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...

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Related Experiment Video

Updated: Jun 27, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Can comprehensive stroke centers erase the 'weekend effect'?

Karen C Albright1, Rema Raman, Karin Ernstrom

  • 1Department of Neurosciences, University of California-San Diego, CA, USA.

Cerebrovascular Diseases (Basel, Switzerland)
|November 29, 2008
PubMed
Summary
This summary is machine-generated.

The "weekend effect" in stroke care may be reduced at comprehensive stroke centers. These centers offer 24/7 specialist access, potentially improving outcomes for weekend stroke admissions.

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Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
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Last Updated: Jun 27, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Area of Science:

  • Neurology
  • Public Health
  • Healthcare Management

Background:

  • Previous studies indicate higher mortality for ischemic stroke patients admitted on weekends, a phenomenon known as the 'weekend effect'.
  • This study aimed to evaluate stroke patient outcomes to ascertain the significance of the 'weekend effect' at two comprehensive stroke centers.

Purpose of the Study:

  • To investigate whether the 'weekend effect' impacts stroke patient outcomes at comprehensive stroke centers.
  • To determine if comprehensive stroke centers mitigate the potential negative effects of weekend admissions on stroke patient mortality and functional outcomes.

Main Methods:

  • Prospective identification of consecutive stroke patients (intracerebral hemorrhage, ischemic stroke without IV t-PA, acute ischemic stroke with IV t-PA, transient ischemic attack).
  • Weekend admission defined as Friday 17:01 to Monday 08:59. Excluded were patients treated beyond 3-hour window, receiving intra-arterial therapy, or in non-observational trials.
  • Compared demographics, NIHSS scores, glucose levels, adverse events, functional outcomes (mRS), and mortality between weekend and weekday admissions.

Main Results:

  • 2,211 stroke patients were analyzed; 36% were admitted on a weekend.
  • No significant differences were observed in symptomatic ICH, discharge mRS, discharge disposition, or 90-day outcomes (mRS, mortality) between weekend and weekday admissions.
  • Multivariate logistic regression, adjusting for key factors, found weekend admission was not a significant independent predictor of in-hospital mortality (OR = 1.10, p = 0.631).

Conclusions:

  • Comprehensive stroke centers (CSCs) may effectively reduce or eliminate the 'weekend effect' for stroke patients.
  • Potential contributing factors include 24/7 availability of stroke specialists, advanced neuroimaging, and specialized nursing care at CSCs.
  • Further prospective studies are needed to confirm these encouraging findings.