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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

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Related Experiment Video

Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Nephrogenic systemic fibrosis].

Tomer Adar1, Deborah Rubinger, Gadi Lalazar

  • 1Internal Medicine Ward A, Hadassah Medical Center, Jerusalem Israel. tomerad@hadassah.org.il

Harefuah
|December 2, 2008
PubMed
Summary
This summary is machine-generated.

Nephrogenic systemic fibrosis (NFS) is a serious condition linked to Gadolinium-based contrast media in patients with kidney failure. Early diagnosis and awareness are crucial for preventing NFS, with CT scans preferred over MRI for at-risk individuals.

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

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Last Updated: Jun 27, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Area of Science:

  • Nephrology
  • Radiology
  • Dermatology

Context:

  • Nephrogenic systemic fibrosis (NFS) is a debilitating fibrotic condition primarily affecting patients with severe renal impairment.
  • NFS is strongly associated with exposure to Gadolinium-based contrast agents (GBCAs) used in Magnetic Resonance Imaging (MRI).
  • The disease presents with significant cutaneous and visceral manifestations, impacting multiple organ systems.

Purpose:

  • To raise awareness of Nephrogenic systemic fibrosis (NFS) among healthcare professionals and patients.
  • To highlight the association between Gadolinium-based contrast media and NFS development in patients with renal failure.
  • To emphasize the importance of diagnostic vigilance and preventive strategies for NFS.

Summary:

  • Nephrogenic systemic fibrosis (NFS) is a progressive disease occurring in patients with renal failure after exposure to Gadolinium (Gd)-based contrast media used in MRI scans.
  • Manifestations of NFS include skin and deep tissue involvement, affecting muscles, lungs, and the heart, with limited treatment options beyond improving renal function.
  • Current FDA guidelines recommend CT scans with iodinated contrast media over MRI with GBCAs for patients with renal failure to mitigate NFS risk.

Impact:

  • Enhancing early diagnosis of Nephrogenic systemic fibrosis (NFS) in susceptible populations.
  • Reducing the incidence of NFS through informed contrast media selection in patients with kidney disease.
  • Improving patient safety in medical imaging by promoting awareness of GBCA-associated risks.