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Study of cholesterol-lowering effect and safety of simvaglisin on rabbit model of hypercholesterolemia
Y I Ragino1, V A Vavilin, N F Salakhutdinov
1N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences. ragino@online.nsk.su
Abstract:
Using rabbit model of experimental hypercholesterolemia we showed that the hypocholesterolemic effect of simvaglisin, a complex preparation containing simvastatin and glycyrrhizic acid, in doses corresponding to 40, 66.5, and 100 mg/kg/day simvastatin is equal to the hypocholesterolemic effect of 200 mg/kg/day simvastatin alone. The total blood cholesterol decreased by 39, 36, 47, and 38% (p < 0.05), respectively, after 20-day course of the preparation. Myotoxicity of simvaglisin evaluated by serum creatine phosphokinase was lower than that of simvastatin. After 30-day treatment, this parameter was lower by 26, 24, and 29% (p < 0.05) than the corresponding parameter for simvastatin.
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