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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Updated: Jun 27, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Prostate cancer stem cells.

S H Lang1, F M Frame, A T Collins

  • 1YCR Cancer Research Unit, Department of Biology, University of York, UK.

The Journal of Pathology
|December 2, 2008
PubMed
Summary
This summary is machine-generated.

Prostate cancer stem cells may drive tumor growth and metastasis, even after hormone therapy. Understanding these cells is key to overcoming treatment resistance.

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Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
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Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Urology

Background:

  • Prostate cancer treatment historically relies on androgen deprivation therapy.
  • Hormone-refractory prostate cancer (HRPC) presents a significant clinical challenge.
  • Tumorigenesis is increasingly linked to cancer stem cells within heterogeneous tumors.

Purpose of the Study:

  • To review the current evidence on prostate cancer stem cells (PCSCs).
  • To discuss the identification and characteristics of normal and malignant prostate stem cells.

Main Methods:

  • Literature review of studies on prostate stem cells.
  • Analysis of evidence regarding PCSC identification and properties.

Main Results:

  • Evidence suggests that prostate tumors contain stem cell-like populations.
  • These prostate cancer stem cells are implicated in tumor initiation, maintenance, and metastasis.
  • Both normal and transformed prostate stem cells have distinct properties.

Conclusions:

  • Prostate cancer stem cells represent a critical area for understanding and treating HRPC.
  • Targeting PCSCs may offer novel therapeutic strategies for resistant prostate cancers.