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Updated: Jun 27, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Catalytic carbonyl addition through transfer hydrogenation: a departure from preformed organometallic reagents
John F Bower1, In Su Kim, Ryan L Patman
1University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station, A5300, Austin, TX 78712-1167, USA.
Abstract:
Classical protocols for carbonyl allylation, propargylation and vinylation typically rely upon the use of preformed allyl metal, allenyl metal and vinyl metal reagents, respectively, mandating stoichiometric generation of metallic byproducts. Through transfer hydrogenative C-C coupling, however, carbonyl addition may be achieved from the aldehyde or alcohol oxidation level in the absence of stoichiometric organometallic reagents or metallic reductants. Here, we review transfer hydrogenative methods for carbonyl addition, which encompass the first catalytic protocols enabling direct C-H functionalization of alcohols.
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