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Updated: Jun 27, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Imaging of recurrent thyroid cancer
1The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institution, Baltimore, MD 21287, USA. naygun1@jhmi.edu
Recent advancements in diagnostic tools have shifted the paradigm for detecting recurrent differentiated thyroid cancer. High-resolution neck ultrasonography and PET/CT are now crucial for identifying recurrent disease.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Well-differentiated thyroid cancer management has evolved.
- New diagnostic technologies have emerged for detecting recurrence.
Purpose of the Study:
- To review current tools for detecting and localizing recurrent differentiated thyroid cancer.
- To discuss the advantages and limitations of various imaging modalities.
Main Methods:
- Review of advancements in serum thyroglobulin assays and recombinant thyrotropin.
- Emphasis on high-resolution neck ultrasonography.
- Evaluation of positron emission tomography (PET)/CT utility.
Main Results:
- Neck ultrasonography is now a primary tool for detecting recurrence.
- Radioiodine (131I) whole body scanning has decreased in importance.
- PET/CT is valuable for cases not detected by other methods.
Conclusions:
- Diagnostic strategies for recurrent thyroid cancer have significantly changed.
- Ultrasonography and PET/CT are key in modern recurrent thyroid cancer detection.
- Understanding the strengths and weaknesses of each modality is vital for patient assessment.
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