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Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
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Synovial Fluid Analysis to Identify Osteoarthritis

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Published on: October 20, 2022

Ossifying synovial sarcoma.

Masanori Hisaoka¹, Atsuji Matsuyama, Shohei Shimajiri

¹Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. hisaoka@med.uoeh-u.ac.jp

Pathology, Research and Practice

|December 2, 2008

Summary

Ossifying synovial sarcoma, a rare soft tissue tumor, presents with bone formation. Molecular analysis confirmed this biphasic synovial sarcoma, highlighting its diverse cellular capabilities.

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Published on: April 12, 2019

Area of Science:

Oncology
Pathology
Genetics

Background:

Synovial sarcoma is a soft tissue sarcoma.
Intralesional calcification is common, but ossification is rare.

Purpose of the Study:

To report a rare case of ossifying synovial sarcoma.
To investigate the tumor's microscopic and molecular characteristics.

Main Methods:

Histopathological examination of tumor tissue.
Reverse transcription-polymerase chain reaction for SS18-SSX1 fusion gene.
Immunohistochemistry for Runx2 expression.

Main Results:

The tumor showed spindle cells, epithelial-like cells, and extensive osteoid formation.
SS18-SSX1 fusion gene transcript confirmed biphasic synovial sarcoma.
Intense Runx2 expression indicated an osteogenic phenotype.

Conclusions:

This case expands the understanding of synovial sarcoma's phenotypic plasticity.
Molecular detection of fusion genes is crucial for diagnosing rare soft tissue sarcomas.
Runx2 expression supports the osteogenic potential in this tumor type.