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Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
Published on: May 26, 2016
Composite fibrous biomaterials for tissue engineering obtained using a supercritical CO2 antisolvent process
C A García-González1, A Vega-González, A M López-Periago
1Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), Campus de la UAB s/n, Bellaterra E-08193, Spain.
Acta Biomaterialia
|December 2, 2008
Summary
Researchers developed biocompatible nanofiber scaffolds using supercritical fluid technology. These composite materials, incorporating titanium dioxide or hydroxyapatite, show promise for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Producing optimal porous scaffolds for tissue engineering remains a challenge.
- Nanofiber-based composites offer potential for advanced scaffold design.
- Biocompatible fillers can enhance scaffold properties for regenerative medicine.
Purpose of the Study:
- To prepare biocompatible nanometric filler-polymer composites for tissue engineering scaffolds.
- To investigate the use of supercritical antisolvent technique for composite fabrication.
- To create fibrous structures with controlled filler distribution.
Main Methods:
- Utilized a supercritical antisolvent (scCO2) technique to produce polymer-nanoparticle composites.
- Suspended inorganic nanopowders (TiO2 or HAP) in polymer solutions (L-PLA or PMMA/PCL).
- Simultaneously sprayed polymer solutions and fillers into scCO2, followed by post-processing into 3D networks.
Main Results:
- Successfully fabricated polymer matrices loaded with 10-20 wt.% inorganic phase.
- Developed two hybrid systems: PMMA/PCL+TiO2 (fibers or microparticles) and L-PLA+HAP (fibers).
- Demonstrated control over morphology (fibers vs. microparticles) by adjusting polymer molecular weight.
Conclusions:
- The supercritical antisolvent technique is effective for creating biocompatible nanofiber composites.
- These composite nanofibers hold significant potential as scaffolds for tissue engineering.
- Further development could lead to optimized scaffolds for regenerative medicine.
