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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
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Published on: August 20, 2021

Genomics made easier: an introductory tutorial to genome datamining.

Peter Schattner1

  • 1Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95065, USA. schattner@soe.ucsc.edu

Genomics
|December 2, 2008
PubMed
Summary
This summary is machine-generated.

This tutorial explores integrated genome databases and genome browsers, simplifying complex tools for researchers. It highlights their effectiveness in medical genetics and alternative splicing analysis, enhancing genomic data interpretation.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Integrated genome databases (e.g., UCSC, Ensembl, NCBI MapViewer) and genome browsers have revolutionized genomic data analysis.
  • The complexity of these powerful tools often limits researchers to using only a fraction of their capabilities.

Purpose of the Study:

  • To provide a tutorial on utilizing advanced features of integrated genome databases and browsers.
  • To demonstrate the application of these tools in medical genetics and alternative splicing research.
  • To highlight the advantages of using these integrated resources over alternative methods.

Main Methods:

  • Utilizing integrated genome databases (UCSC, Ensembl, NCBI MapViewer).
  • Employing genome browsers for data querying and visualization.
  • Illustrating techniques with examples from medical genetics and alternative splicing.

Main Results:

  • Demonstrated biological questions addressable with advanced genome database functionalities.
  • Showcased the superior effectiveness of integrated tools compared to alternative methods.
  • Identified resources for further learning on advanced capabilities.

Conclusions:

  • Integrated genome databases and browsers offer powerful, yet underutilized, capabilities for biological research.
  • Mastering these tools enhances the analysis of complex genomic data, particularly in fields like medical genetics.
  • Further exploration of advanced features can significantly improve research efficiency and discovery.