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Updated: Jun 27, 2026
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Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
Published on: June 30, 2017
Before they were fat: adipocyte progenitors.
Kye Won Park1, Daniel S Halperin, Peter Tontonoz
1Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.
Cell Metabolism
|December 2, 2008
Summary
Adult adipose tissue expansion requires ready adipocyte precursor cells. New studies reveal distinct immature cell populations that form brown and white fat, aiding research into obesity and diabetes.
Area of Science:
- Cell biology
- Metabolic research
- Adipogenesis
Background:
- Adipose tissue mass expands throughout adult life, necessitating a constant supply of adipocyte precursors.
- Energy storage demands require a responsive system for generating new fat cells.
Purpose of the Study:
- To identify and characterize immature cell populations involved in adipogenesis.
- To provide tools for studying the regulation of adipogenesis in metabolic diseases.
Main Methods:
- Identification of discrete immature cell populations.
- Characterization of precursor cells for brown and white adipocytes.
Main Results:
- Discovery of distinct immature cell populations giving rise to both brown and white adipocytes.
- New insights into the fundamental mechanisms of adipose tissue formation.
Conclusions:
- Adipogenesis involves specific immature cell precursors.
- This research offers novel tools for investigating adipogenesis in obesity and diabetes.
