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Published on: September 20, 2017
Application of the solvation parameter model in method development for analysis of residual solvents in
1National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.
Abstract:
The solvation parameter model was applied in the development of a method for the analysis of residual solvents in pharmaceuticals. The interactions between organic solvents and six different stationary phases were studied using gas chromatography. The retention times of the organic solvents on these columns could be predicted under isothermal or temperature-programmed conditions using the established solvation parameter models. The predicted retention times helped in column selection and in optimizing chromatographic conditions during method development, and will form the basis for the development of a computer-aided method.
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