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Updated: Jun 27, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Apoptosis in lung injury and fibrosis
F Drakopanagiotakis1, A Xifteri, V Polychronopoulos
1Interstitial Lung Disease Study Group, 3rd Dept of Pneumonology, Sismanoglio General Hospital, Athens, Greece.
Abstract:
Pulmonary fibrosis is characterised by fibroblast accumulation and alveolar epithelium denudation. Increased apoptosis of alveolar epithelial cells and decreased apoptosis of fibroblasts may play an important role in the pathogenesis of disease. Inflammatory cells can modulate apoptosis of other cell types, both by removal of apoptotic debris and by cytokine production, thus preserving a pro-fibrotic environment. In the present review, some of the mechanisms by which apoptosis may contribute to the pathogenesis of idiopathic pulmonary fibrosis are described.
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