Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ldha Regulates Osteosarcoma Lung Metastasis through Hedgehog Signaling.

Cancer research communications·2026
Same author

S100A4-TLR4-TGF-β axis as a therapeutic target for Dupuytren's contracture in diabetic patients.

Cell death discovery·2026
Same author

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Aging cell·2026
Same author

PHF2 regulates grip strength via demethylation at the promoter region of the <i>Mef2c</i>.

iScience·2026
Same author

β-Nicotinamide mononucleotide preserves muscle strength in septic male mice.

Scientific reports·2026
Same author

Dissecting Hhip1 Function <i>In Vivo</i> Using a Conditional Knockout Mouse Model.

Acta histochemica et cytochemica·2026

Related Experiment Video

Updated: Jun 27, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

[The state and perspective in bone regeneration].

Yuuki Imai1, Kunio Takaoka

  • 1Osaka City University Graduate School of Medicine, Department of Orthopaedic Surgery, Japan.

Clinical Calcium
|December 2, 2008
PubMed
Summary
This summary is machine-generated.

Bone regeneration for large defects faces challenges with current bone graft methods. This review explores bone morphogenetic proteins (BMPs) as a promising alternative for enhanced bone healing in orthopaedics.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
07:29

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
07:29

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Area of Science:

  • Orthopaedic surgery
  • Regenerative medicine
  • Biomaterials science

Background:

  • Treatments for bone and joint conditions have advanced, particularly in orthopaedics with alternatives to total joint arthroplasty and spinal fusion.
  • Current methods for massive bone defects and extensive spinal fusion often rely on autografts, which have limitations.
  • Autografts can lead to insufficient bone regeneration and donor site morbidity.

Purpose of the Study:

  • To review the current perspectives and underlying biology of bone regeneration.
  • To highlight the potential of bone morphogenetic proteins (BMPs) in addressing limitations of current bone grafting techniques.
  • To discuss BMPs as a therapeutic strategy for challenging orthopaedic conditions.

Main Methods:

  • Literature review focusing on bone regeneration mechanisms.
  • Analysis of studies investigating bone morphogenetic proteins (BMPs) in bone healing.
  • Exploration of biological pathways involved in BMP-mediated bone formation.

Main Results:

  • Bone morphogenetic proteins (BMPs) play a crucial role in osteogenesis and bone healing.
  • BMPs offer a promising biological approach to enhance bone regeneration compared to traditional grafts.
  • Research indicates potential for BMPs in treating massive bone defects and facilitating spinal fusion.

Conclusions:

  • Bone morphogenetic proteins (BMPs) represent a significant advancement in bone regeneration strategies.
  • BMPs hold the potential to overcome the limitations associated with autografting in orthopaedic procedures.
  • Further research and clinical application of BMPs could revolutionize the treatment of bone defects and spinal fusion.