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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jun 27, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

[Articular cartilage regeneration using stem cells].

Takashi Kanamoto¹, Norimasa Nakamura, Ken Nakata

¹Osaka University Graduate School of Medicine, Department of Orthopaedic Surgery, Japan.

Clinical Calcium

|December 2, 2008

Summary

Articular cartilage damage can lead to osteoarthritis. This review discusses using stem cells, like bone marrow or synovial-derived mesenchymal cells, for cartilage repair, offering new therapeutic avenues.

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Last Updated: Jun 27, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

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Area of Science:

Orthopedics and Regenerative Medicine
Biomedical Engineering
Cell Biology

Background:

Articular cartilage is crucial for joint function and shock absorption but has limited self-healing capacity.
Chondral injuries can progress to osteoarthritis (OA), posing a significant clinical challenge.
Current cartilage repair strategies include marrow stimulation, osteochondral transplantation, and autologous chondrocyte implantation (ACI).

Purpose of the Study:

To review the potential of stem cell therapy for articular cartilage repair.
To discuss the application of mesenchymal stem cells derived from bone marrow and synovium.
To explore advancements in regenerative approaches for chondral defects.

Main Methods:

Literature review of current cartilage repair techniques.
Analysis of recent stem cell research in cartilage regeneration.
Discussion of mesenchymal stem cell sources and their therapeutic potential.

Main Results:

Autologous chondrocyte implantation (ACI) has a successful clinical history with over 20,000 procedures worldwide.
Stem cell research shows promise for enhancing cartilage repair efficacy.
Mesenchymal stem cells from bone marrow and synovium are key candidates for regenerative therapies.

Conclusions:

Stem cell therapy, particularly using mesenchymal stem cells, represents a promising frontier in cartilage repair.
Further research into stem cell applications could lead to improved treatments for chondral injuries and osteoarthritis.
Regenerative medicine offers potential solutions for the clinical challenge of cartilage defect repair.