[Regenerative medicine in bone tumor surgery]

In bone tumor surgery, target of bone tissue engineering technique will be the reconstruction of large bone void after tumor excision. It may be also useful to accelerate the regeneration of processed autologous bone grafts such as irradiated bone. Interconnected porous ceramics bone substitutes have been considered to be useful as a scaffold for bone engineering. We started a clinical trial on bone regeneration to evaluate its safety and efficiency using mesenchymal stem cells derived from autologous bone marrow aspirates and porous hydroxyapatite ceramics as a scaffold. In this study, after osteoblastic differentiation culture for several weeks, cells integrated to porous ceramics are transplanted into the defect after removal of large benign bone tumor.