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Effect of zwitterionic polymers on wound healing
Shigeto Fujishita1, Chika Inaba, Susumu Tada
1Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, Japan.
Biological & Pharmaceutical Bulletin
|December 2, 2008
Summary
A novel zwitterionic copolymer film (poly(CMB-r-BMA)) significantly accelerated excisional wound healing in rats by reducing protein adsorption and neutrophil adhesion. This biomaterial shows promise as an advanced wound dressing.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background:
- Wound healing is a complex biological process influenced by biomaterial interactions.
- Developing advanced wound dressings is crucial for improving patient outcomes.
- Zwitterionic polymers offer unique surface properties beneficial for biomedical applications.
Purpose of the Study:
- To evaluate the efficacy of a zwitterionic random copolymer film, poly(carboxybetaine [1-carboxy-N,N-dimethyl-N-(2'-methacryloyloxyethyl)methanaminium inner salt] -co-n-butyl methacrylate) (poly(CMB-r-BMA)), as a wound dressing.
- To compare its performance in promoting the healing of excisional and incisional wounds in hairless rats against control materials.
Main Methods:
- A thin film of poly(CMB-r-BMA) (30 mol% CMB) was applied to full-thickness excisional and incisional wounds in hairless rats.
- Wound healing was assessed by comparing closure rates and complete healing.
- Protein adsorption and neutrophil adhesion onto the film surfaces were quantified and compared with poly(n-butyl methacrylate) (PBMA) and poly(ethylene terephthalate) (PET) films.
Main Results:
- The poly(CMB-r-BMA) film significantly enhanced wound closure and complete healing of excisional wounds compared to PBMA and PET films.
- No significant enhancement in healing was observed for incisional wounds treated with the poly(CMB-r-BMA) film.
- Protein adsorption and neutrophil adhesion were significantly lower on the poly(CMB-r-BMA) film than on PBMA and PET films.
- The poly(CMB-r-BMA) film demonstrated superior performance compared to a commercial wound dressing (Tegaderm) for excisional wounds.
Conclusions:
- The zwitterionic poly(CMB-r-BMA) film effectively accelerates the healing of excisional wounds, likely by modulating the wound environment.
- Reduced protein adsorption and neutrophil adhesion on the poly(CMB-r-BMA) film contribute to its enhanced wound healing properties.
- This copolymer film holds significant potential as a novel and effective wound dressing material.
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