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Published on: February 15, 2016
Preparation and prodrug studies of quercetin pentabenzensulfonate
You Peng1, Zeyuan Deng, Chunfeng Wang
1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Abstract:
Pentabenzensulfonate (QPBS), a potential prodrug for quercetin, was designed and synthesized in high yield. It possesses better physical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.04) and the half-life of the hydrolysis value (3.85 h) show that oral bioavailability is improved evidently compared with that of quercetin. These results indicate that QPBS can be considered as a potential prodrug for quercetin.
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