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Updated: Jun 27, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

High-resolution mapping of copy-number alterations with massively parallel sequencing

Derek Y Chiang1, Gad Getz, David B Jaffe

  • 1Broad Institute, Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA.

Nature Methods
|December 2, 2008
PubMed
Summary

Massively parallel sequencing can detect cancer copy-number alterations with precision comparable to DNA microarrays. This technology offers improved breakpoint localization, aiding in the discovery of cancer-causing genes.

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