Related Experiment Video
Updated: Jun 27, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Fasting total homocysteine (tHcy) concentration and mortality in older Mexican Americans
V Colon Lopez1, M N Haan, A E Aiello
1Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI, USA. vicolon@rcm.upr.edu
Objectives:
This study examines the association between tHcy on cardiovascular and noncardiovascular mortality.
Design:
Longitudinal study of 1,633 Mexican Americans age>60 years recruited in 1998.
Setting:
Sacramento, California.
Measurements:
Cox proportional models were used to estimate the effects of tHcy on mortality rate in the total sample and in a subgroup of subjects without a history of cardiovascular disease at baseline.
Results:
About half of the cohort was born in Mexico. Among Mexican-born participants, high tHcy (>11.0 micromol/L) was associated with a higher rate of cardiovascular mortality compared to those with low tHcy concentration
Conclusions:
The effect of tHcy on cardiovascular mortality is nearly 40% stronger among the immigrant group. tHcy might be an early marker of subclinical vascular pathology amongst the Mexican-born group, despite their apparently healthy profile at baseline.
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