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Updated: Jun 27, 2026
05:14
Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher
Published on: February 23, 2018
Adaptive calibration of dynamic accommodation--implications for accommodating intraocular lenses
Clifton M Schor1, Shrikant R Bharadwaj
1School of Optometry & Vision Science, University of California at Berkeley, Berkeley, CA 94720, USA. schor@socrates.berkeley.edu
Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|December 3, 2008
Summary
Neural recalibration can restore optimal accommodative responses after intraocular lens (IOL) replacement. The human eye
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Neuroscience
Background:
- Aging leads to loss of natural lens accommodation.
- Prosthetic accommodating intraocular lenses (IOLs) aim to restore this function.
- Differences in viscoelasticity between IOLs and natural lenses can cause accommodative mismatches.
Purpose of the Study:
- To investigate if neural control recalibration can optimize accommodation with new IOLs.
- To determine if the human accommodative system can adapt to altered lens biomechanics.
Main Methods:
- Computer simulations modeled dynamic accommodation with two IOL prototypes.
- Human experiments used a double-step adaptation paradigm to simulate changes in lens biomechanics.
- Neural recalibration effects on dynamic accommodation were analyzed.
Main Results:
- Simulations suggested neural recalibration can correct accommodative oscillations and sluggishness caused by IOL mismatches.
- Empirical data confirmed the accommodative system's capacity for adaptive recalibration.
- The system adapted to optical loads mimicking altered lens properties.
Conclusions:
- The accommodative system demonstrates adaptive capabilities to compensate for biomechanical changes introduced by accommodating IOLs.
- Neural recalibration is a potential strategy to improve visual outcomes after accommodating IOL implantation.
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