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Related Experiment Videos

Development in Myxococcus xanthus involves differentiation into two cell types, peripheral rods and spores.

K A O'Connor1, D R Zusman

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Journal of Bacteriology
|June 1, 1991
PubMed
Summary

Myxococcus xanthus starvation triggers fruiting body formation. This study identifies peripheral rods as a distinct cell type, separate from spores, revealing a new developmental pathway in this bacterium.

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Area of Science:

  • Microbiology
  • Bacterial Development
  • Cell Biology

Background:

  • Myxococcus xanthus exhibits complex multicellular development upon starvation.
  • Most cells form fruiting bodies and differentiate into spores, but some remain non-aggregated.

Purpose of the Study:

  • To investigate the biology and physiology of non-aggregated cells in Myxococcus xanthus.
  • To characterize peripheral rods as a distinct cell type.

Main Methods:

  • Developed a technique to separate aggregated and non-aggregated cells.
  • Isolated differentiating cells at various developmental stages.
  • Characterized gene expression in aggregated and non-aggregated cells.

Main Results:

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  • Identified and described peripheral rods, cells remaining outside aggregates.
  • Documented the presence of peripheral rods in multiple wild-type strains.
  • Showed cell-type-specific expression patterns for genes like myxobacterial hemagglutinin, protein S (Tps), protein S1 (Ops), and protein C, as well as phosphatase activities.

    • Conclusions:

    • Peripheral rods represent a distinct cell type in Myxococcus xanthus, separate from vegetative cells and spores.
    • This discovery introduces a second late developmental cell type, opening new research avenues into M. xanthus differentiation regulation.