Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temperature effects on photosensitized processes.

V Gottfried1, S Kimel

  • 1Department of Chemistry, Technion-Israel Institute of Technology, Haifa.

Journal of Photochemistry and Photobiology. B, Biology
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CT-like images based on T1-weighted gradient echo MRI sequences for the assessment of fractures of the hand and wrist compared to CT.

Skeletal radiology·2024
Same author

Delayed fluorescence of porphyrins in different media.

Journal of fluorescence·2013
Same author

Spatially selective photocoagulation of biological tissues: feasibility study utilizing cryogen spray cooling.

Applied optics·2010
Same author

Wavelength shifts in tuning dye lasers.

Applied optics·2010
Same author

Temporal approach to the calculation of the spectral response of optical cavities and filters.

Applied optics·2010
Same author

Cooling efficiency of cryogen spray during laser therapy of skin.

Lasers in surgery and medicine·2003
Same journal

Engineering liposomes via click chemistry for multimodal biomedical applications: Evidence from eukaryotic transfection and antimicrobial light-triggered therapy.

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

Phytofabrication of Chitosan-MgO nanocomposites: Evaluation of their antioxidant, antibacterial, anticancer, and zebrafish embryo biocompatibility properties.

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

Ocean acidification exacerbates UVR-induced inhibition of photosystem II and I in Corallina officinalis.

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

Application of a sulfonic acid-modified NE probe with low-toxicity in a mouse model of pneumonia.

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

Corrigendum to 'Wavelength-dependent photobiomodulation attenuates synovial inflammation in fibroblast-like synoviocytes and a collagenase-induced osteoarthritis model' [Journal of Photochemistry & Photobiology B: Biology Volume 272 (2025) 113276].

Journal of photochemistry and photobiology. B, Biology·2026
Same journal

On-demand H₂S delivery from NIR-activated dithiocarbamate-functionalized AuAg microdroplets for cellular anti-inflammation.

Journal of photochemistry and photobiology. B, Biology·2026
See all related articles

Increasing temperature significantly accelerates singlet oxygen reactions with various chemical acceptors, like imidazole and tryptophan. These findings suggest potential synergy between hyperthermia and photodynamic therapy for enhanced treatment efficacy.

Area of Science:

  • Photochemistry
  • Chemical Kinetics
  • Biomedical Applications

Background:

  • Singlet oxygen is a reactive oxygen species crucial in photodynamic therapy (PDT).
  • Understanding the kinetics of singlet oxygen reactions is vital for optimizing PDT efficacy.
  • Meso-tetraphenylporphine tetrasulphonate (TPPS4) is a photosensitizer used in PDT research.

Purpose of the Study:

  • To investigate the temperature dependence of singlet-oxygen-mediated reactions with various chemical acceptors.
  • To quantify the reaction rate increases for specific acceptors over a defined temperature range.
  • To explore the implications for combining hyperthermia with photodynamic therapy.

Main Methods:

  • Spectroscopic and electrochemical monitoring of reagent consumption in real-time.

Related Experiment Videos

  • Studying reactions in buffered aqueous solutions with TPPS4 as the photosensitizer.
  • Varying temperature between 15-45°C and analyzing changes in reaction rates.

    • Main Results:

    • Reaction rates increased significantly with temperature for all tested acceptors.
    • Imidazole showed the highest rate increase (210%), followed by furfuryl alcohol (150%).
    • Tryptophan (86%) and RNO (90%) also exhibited substantial rate enhancements.

    Conclusions:

    • Temperature significantly influences singlet oxygen reaction kinetics, enhancing reaction rates with common acceptors.
    • The observed rate increases support the potential synergistic effects of hyperthermia and PDT.
    • Further research is warranted to translate these findings into clinical PDT strategies.