Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stone Masonry01:29

Stone Masonry

Stone masonry is a construction technique that uses individual stones to build structures and can be categorized into two main types: rubble and ashlar. Rubble masonry uses uneven, naturally shaped stones such as river rocks or fragments from quarries. This method often requires the mason to select and possibly shape each stone to fit the designated space, ensuring a proper build, even with irregular stone sizes and shapes. Ashlar masonry, on the other hand, employs uniformly cut stones that...
Quarrying of Stone01:15

Quarrying of Stone

Quarrying is the process of extracting stone from a quarry, where specialized techniques are employed to remove large blocks of stone safely and efficiently. This process can involve controlled explosions or more precision-oriented methods such as cutting and drilling.
One common method involves using a diamond belt saw to cut large blocks from the quarry face. These blocks can be about 50 feet long and 12 feet high. After the initial vertical cut, drilling is performed at the base of the block.
Masonry Paving01:21

Masonry Paving

The construction of masonry paving involves using materials such as bricks, stones, and concrete masonry units. These materials are chosen for their shape, color, strength, and resistance to abrasion and weathering. Masonry units can be installed dry on a thin layer of sand and a gravel base, or they can be embedded in mortar or asphalt on a concrete slab. For areas subjected to heavy vehicular loads, a rigid base layer of reinforced or unreinforced concrete is recommended. In contrast,...
Mortar Joint Deterioration in Masonry01:13

Mortar Joint Deterioration in Masonry

Mortar joint deterioration is a significant concern in masonry structures, with water accumulation in the joints leading to damage from freeze-thaw cycles. The repeated expansion of water during freezing and its melting during thawing develop and propagate cracks in the masonry joints. Eventually, this leads to the spalling of mortar from the joints, loosening masonry units and weakening the structure. The deteriorated mortar joints are also vulnerable to moisture intrusion into the walls.
The...
Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
Types of Building Stone01:30

Types of Building Stone

Building stones, essential materials for construction, are extracted from natural rock deposits and processed into specific forms and dimensions suitable for various building applications. These stones are broadly classified into three types based on their geological formation: igneous, sedimentary, and metamorphic.
Igneous rocks are formed from the solidification of magma or lava. An example is granite, known for its durability and resistance to weathering, making it ideal for parts of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shadow Hamiltonian in molecular dynamics simulations: Against a possible suggested misuse of its physical meaning.

The Journal of chemical physics·2026
Same author

Targeting primary and metastatic ovarian cancer with a peptide derived from the human NAF-1/CISD2 protein.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

The scientific legacy of Martin Karplus from the perspective of his collaborators.

Biophysical journal·2026
Same author

Model-Free Learning of Probability Flows: Elucidating the Nonequilibrium Dynamics of Flocking.

Physical review letters·2025
Same author

The Dawn of Alchemical Free-Energy Methods in Biomolecular Simulations.

The journal of physical chemistry. B·2025
Same author

Determining Pathways of Minimum Work: Simple Examples.

Molecular physics·2025
Same journal

Anharmonic phonons via quantum thermal bath simulations.

The Journal of chemical physics·2026
Same journal

Quantum simulation of alignment dependent differential cross sections in co-propagating molecular beams at cold collision energies.

The Journal of chemical physics·2026
Same journal

Non-additive ion effects on the coil-globule equilibrium of a generic polymer in aqueous salt solutions.

The Journal of chemical physics·2026
Same journal

Insights into the unexpected small reduction of the temperature of maximum density of water by lithium chloride addition.

The Journal of chemical physics·2026
Same journal

Optical frequency comb double-resonance spectroscopy of the 9030-9175 cm-1 states of ethylene.

The Journal of chemical physics·2026
Same journal

Time reversal breaking of colloidal particles in cells.

The Journal of chemical physics·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

On the assumptions underlying milestoning.

Eric Vanden-Eijnden1, Maddalena Venturoli, Giovanni Ciccotti

  • 1Courant Institute of Mathematical Sciences, New York University, New York, New York 10012, USA. eve2@cims.nyu.edu

The Journal of Chemical Physics
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

Milestoning accurately models complex molecular dynamics by analyzing transitions between states. Optimal milestones ensure independent transitions, enabling precise calculation of mean first passage times.

Related Experiment Videos

Last Updated: Jun 27, 2026

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

Area of Science:

  • Computational Chemistry
  • Statistical Mechanics
  • Molecular Dynamics

Background:

  • Milestoning is a computational method for analyzing complex molecular processes.
  • It relies on molecular dynamics (MD) simulations between predefined states (milestones).
  • Key assumptions involve statistical independence of transitions and time lags between milestones.

Purpose of the Study:

  • To rigorously analyze the validity of milestoning assumptions.
  • To identify conditions under which milestones ensure statistically independent transitions.
  • To investigate the computation of mean first passage times.

Main Methods:

  • Utilizing transition path theory and isocommittor surfaces to define optimal milestones.
  • Analyzing the statistical independence of successive transitions.
  • Deriving reinitialization probability distributions for overdamped systems.

Main Results:

  • Demonstrated the existence of optimal milestone sets ensuring statistically independent transitions.
  • Derived reinitialization probability distributions for overdamped systems.
  • Showed that time lags remain dependent but mean first passage times can be computed exactly.

Conclusions:

  • Optimal milestones, derived from transition path theory, validate key milestoning assumptions.
  • The method allows exact computation of mean first passage times, enhancing its applicability.
  • Findings offer practical insights and comparisons with Markov state models.