Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

50.4K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
50.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of the aluminium in situ bioaccumulation in the evolutive state of carotid atheromatous plaques.

Ecotoxicology and environmental safety·2026
Same author

Chronic Styrene Exposure Causes Oxidative Stress, Neuroinflammation, and Hippocampal Memory Dysfunction via NLRP3 Inflammasome Activation.

Molecular neurobiology·2025
Same author

Targeting NLRP3 inflammasome activation in styrene-induced ototoxicity: comparative efficacy of rosmarinic acid and anakinra in mitigating oxidative and inflammatory damage.

International journal of audiology·2025
Same author

Lead bioaccumulation in human breast cancer tissue is associated with DNA instability and cell death resistance.

Cell death discovery·2025
Same author

Active control of transverse viscoelastic damping in the tectorial membrane: A second mechanism for traveling-wave amplification?

Hearing research·2025
Same author

Contribution of the reticular lamina motion to the traveling wave: a WKB approach.

Hearing research·2025

Related Experiment Video

Updated: Jan 13, 2026

Performing Intracochlear Electrocochleography During Cochlear Implantation
09:10

Performing Intracochlear Electrocochleography During Cochlear Implantation

Published on: March 8, 2022

4.9K

Transient evoked otoacoustic emission input/output function and cochlear reflectivity: experiment and model.

Renata Sisto1, Arturo Moleti

  • 1Dipartimento Igiene del Lavoro, ISPESL, Via Fontana Candida, 1, 00040 Monte Porzio Catone (Roma), Italy. renata.sisto@ispesl.it

The Journal of the Acoustical Society of America
|December 3, 2008
PubMed
Summary

Transient evoked otoacoustic emissions (TEOAEs) are best explained by linear reflection, not nonlinear distortion, across various stimulus levels. Cochlear reflectivity is dominated by rapidly rotating phase components, challenging existing assumptions in auditory research.

More Related Videos

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

14.6K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

15.0K

Related Experiment Videos

Last Updated: Jan 13, 2026

Performing Intracochlear Electrocochleography During Cochlear Implantation
09:10

Performing Intracochlear Electrocochleography During Cochlear Implantation

Published on: March 8, 2022

4.9K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

14.6K
Optogenetic Stimulation of the Auditory Nerve
10:53

Optogenetic Stimulation of the Auditory Nerve

Published on: October 8, 2014

15.0K

Area of Science:

  • Auditory Neuroscience
  • Acoustics
  • Biophysics

Background:

  • Transient evoked otoacoustic emissions (TEOAEs) are crucial for assessing cochlear function.
  • Understanding the underlying mechanisms of TEOAE generation, including linear reflection and nonlinear distortion, is essential.
  • Previous models often emphasize nonlinear distortion at higher stimulus levels.

Purpose of the Study:

  • To evaluate the input/output function of TEOAEs at different stimulus levels.
  • To compare experimental data with theoretical models, specifically one-dimensional transmission-line models.
  • To investigate the contribution of different mechanisms, including linear reflection, nonlinear distortion, and a novel wave-fixed scattering potential, to TEOAE generation.

Main Methods:

  • Experimental measurement of TEOAEs across various stimulus levels.
  • Fitting experimental response functions to theoretical reflectivity functions from 1D transmission-line models.
  • Analysis of phase-gradient delay and comparison with wavelet time-frequency latency measurements.
  • Consideration of linear reflection (place-fixed), nonlinear distortion (wave-fixed), and a wave-fixed scattering potential.

Main Results:

  • Experimental TEOAE response functions were best fitted by reflectivity functions in the perturbative limit.
  • Linear reflection from roughness provided a good fit across stimulus levels and frequencies.
  • Neither nonlinear distortion nor scale-invariance violation significantly contributed to the observed TEOAEs.
  • Phase-gradient delay measurements were consistent with wavelet time-frequency latency, supporting the dominance of a rapidly rotating phase component.

Conclusions:

  • Cochlear reflectivity is primarily governed by a rapidly rotating phase component, irrespective of stimulus level.
  • This finding challenges the conventional assumption that nonlinear distortion significantly contributes to TEOAEs at high stimulus levels.
  • The study suggests linear reflection is a dominant mechanism in TEOAE generation, necessitating a re-evaluation of current auditory models.