Related Experiment Video
Updated: Jun 27, 2026
02:43
Importance of Jumping Ability in Handball Throwing Speed and Accuracy
Published on: April 4, 2025
Jumping higher: is it still possible? The ALTTO trial challenge
Gianluca Tomasello1, Evandro de Azambuja, Phuong Dinh
1Institute Jules Bordet, Université Libre de Bruxelles, 121 Boulevard de Waterloo, 1000, Brussels, Belgium.
Expert Review of Anticancer Therapy
|December 3, 2008
Summary
This study compares trastuzumab and lapatinib for early-stage HER2-positive breast cancer. It aims to determine the most effective anti-HER2 agent and optimal administration schedule for improved survival and reduced recurrence.
Area of Science:
- Oncology
- Pharmacology
- Clinical Trials
Background:
- Trastuzumab improves survival in metastatic and early HER2-positive breast cancer.
- Lapatinib, a tyrosine kinase inhibitor, shows promise in advanced breast cancer and has a favorable safety profile.
Purpose of the Study:
- To compare the efficacy of trastuzumab and lapatinib in early-stage HER2-positive breast cancer.
- To determine the optimal administration schedule (separate, sequential, or combination) for anti-HER2 agents.
Main Methods:
- The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimisation (ALTTO) trial is a four-arm randomized study.
- Enrollment of 8000 patients worldwide with early-stage HER2-positive breast cancer.
Main Results:
- N/A - Results not yet available in the abstract.
Conclusions:
- N/A - Conclusions not yet available in the abstract.
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