Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy of inulin supplementation in metabolic control and Akkermansia muciniphila levels in subjects with type 1 diabetes: a pilot study.

European review for medical and pharmacological sciences·2026

Same author

Glucose metrics and device satisfaction in adults with type 1 diabetes using different treatment modalities: a multicenter, real-world observational study.

Acta diabetologica·2024

Same author

Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study.

European journal of pediatrics·2024

Same author

Efficacy of "Physiology-Guided PCI" Using Pressure Catheter in Comparison to Conventional Pressure Wires: A Multicenter Analysis.

The American journal of cardiology·2024

Same author

Landfill leachate from Municipal Solid Waste: Multi-technique approach for its fine characterization and determination of the thermodynamic and sequestering properties towards some toxic metals.

The Science of the total environment·2024

Same author

Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study.

European journal of nuclear medicine and molecular imaging·2023

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Association between reduced pulmonary diffusing capacity and cardiac autonomic dysfunction in Type 1 diabetes.

D Pitocco¹, P Santangeli, L Fuso

¹Cardiology Institute, Catholic University, Rome, Italy. dario.pitocco@rm.unicatt.it

Diabetic Medicine : a Journal of the British Diabetic Association

|December 3, 2008

Summary

Autonomic nervous system dysfunction in Type 1 diabetes is linked to reduced lung diffusion capacity. Heart rate variability measures show this association, even without other clinical signs.

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

Related Experiment Videos

Last Updated: Jun 27, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

Area of Science:

Cardiology
Pulmonology
Endocrinology

Background:

Autonomic nervous system dysfunction (NAD) may impair lung diffusion capacity in Type 1 diabetes mellitus (DM).
Heart rate variability (HRV) is a sensitive indicator of cardiac autonomic function and NAD.
Previous studies have not explored the link between cardiac sympatho-vagal balance and lung diffusion capacity in diabetes.

Purpose of the Study:

To investigate the association between cardiac autonomic function and lung diffusion capacity in Type 1 DM patients.
To determine if HRV parameters correlate with lung diffusion capacity in this population.

Main Methods:

Twenty Type 1 DM patients without pulmonary or systemic NAD were studied.
Lung diffusion capacity for carbon monoxide (DLCO) was measured using the single-breath method.
Cardiac autonomic function was assessed via 24-hour Holter recordings and HRV analysis.

Main Results:

Standard respiratory and peripheral autonomic tests were normal in all participants.
Six patients (30%) exhibited DLCO values lower than normal reference ranges.
DLCO showed significant correlations with most HRV variables, notably SDNN and LF power, independent of other clinical factors.

Conclusions:

A significant association exists between cardiac NAD and reduced DLCO in Type 1 diabetes, even without overt clinical abnormalities.
NAD may contribute to early DLCO reduction in Type 1 DM, potentially via altered pulmonary microvascular blood flow regulation.