Related Experiment Video
Updated: Jun 27, 2026
05:46
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Canine ocular gliomas: a retrospective study
Carolina Naranjo1, Charles Schobert, Richard Dubielzig
1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Wisconsin, USA.
Veterinary Ophthalmology
|December 3, 2008
Summary
This study classified canine gliomas in the retina and optic nerve, finding that while metastatic potential is low, brain invasion can occur. These findings aid in diagnosing intraocular and orbital masses in dogs.
Area of Science:
- Veterinary Ophthalmology
- Canine Pathology
- Neoplasia
Background:
- Glial tumors in the canine eye are uncommon but significant causes of vision loss.
- Accurate classification and understanding of prognosis are crucial for affected animals.
Purpose of the Study:
- To classify glial tumors in the canine retina and optic nerve.
- To describe their histopathological features.
- To provide prognostic information for canine gliomas.
Main Methods:
- Retrospective analysis of 18 canine glioma cases from the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) database.
- Histopathological review and classification of neoplasms.
- Immunohistochemistry for Glial Fibrillary Acidic Protein (GFAP) was performed.
Main Results:
- 18 canine gliomas were identified with no breed or gender predilection; mean age was 9.33 years.
- Survival time varied, with 8 of 12 dogs with follow-up information deceased, often with tumor extension at the optic nerve margin.
- Tumors were classified as astrocytomas (low, medium, high grade) and oligodendroglioma; GFAP was positive in most cases.
Conclusions:
- Canine retinal and optic nerve gliomas are important differential diagnoses for intraocular and orbital masses.
- Metastatic potential is generally low, but invasion into the brain is a possibility.