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Related Experiment Video

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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

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Abnormal cardiac structure and function in the metabolic syndrome: a population-based study.

Bilal Aijaz¹, Khawaja A Ammar, Francisco Lopez-Jimenez

¹Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Mayo Clinic Proceedings

|December 3, 2008

Summary

Isolated metabolic syndrome is linked to early heart dysfunction in women, showing increased left ventricular mass and diastolic issues. This finding highlights potential cardiovascular risks in women with metabolic syndrome without hypertension or diabetes.

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Published on: January 19, 2017

Area of Science:

Cardiology
Metabolic Disorders
Echocardiography

Background:

Metabolic syndrome is a cluster of conditions increasing cardiovascular risk.
Isolated metabolic syndrome excludes hypertension and diabetes, offering a unique focus.
Cardiac structure and function changes may precede overt cardiovascular disease.

Purpose of the Study:

To investigate the association between cardiac abnormalities and isolated metabolic syndrome.
To determine if isolated metabolic syndrome is linked to early signs of cardiac dysfunction.

Main Methods:

Prospective, population-based study of 2042 residents aged 45+.
Echocardiography used to assess cardiac structure and function.
Metabolic syndrome defined by National Cholesterol Education Program Adult Treatment Panel III criteria.

Main Results:

Prevalence of isolated metabolic syndrome was 16.7% in women and 21.7% in men.
Women with isolated metabolic syndrome showed higher left ventricular (LV) mass index and LV diastolic dysfunction.
A stepwise increase in LV abnormalities was observed with increasing metabolic syndrome severity in both sexes.

Conclusions:

Isolated metabolic syndrome is associated with increased LV mass and diastolic dysfunction in women.
This suggests isolated metabolic syndrome identifies women with early signs of ventricular dysfunction.
Further research could explore targeted interventions for this population.